The primary theme of Houses of the Blood MUSH is struggle. Vampires are not the most dominant species of supernatural, even though they are one of the most numerous. Beset from without by enemies and fractious alliances, beset from within by political strife and the decadence of their own society, the nightly existence of the vampire can be a struggle.
The secondary theme of Houses of the Blood MUSH is the aforementioned decadence and its effect on both vampire society and the world around them. Vampire society has grown out of a fattened, self-absorbed Roman society. Though some of the fat has been trimmed in the intervening centuries, the Senex Sanguinem and the Republic of the Night still exist in a state of self-aggrandizement. And within, we find the core of the vampiric struggle: maintaining their existence in vampiric society, and the balancing act that requires to be active in human society and not lose yourself to the ennui of ages. It is here that the vampire political structure shows, and what vampires do to get ahead.
All of this is set against a backdrop of the modern world, a modern world where vampires exist alongside other supernatural creatures and mortals. And therein we find another aspect of our core 'struggle'. Vampires are not alone. They are above mortals, surely; but they need mortals to survive. And mortals, en masse, pose a problem to the vampires. Ultimately, the balancing act of interacting with human society falls to the individual vampire, but the struggle is there. Maintaining friendships and connections, finding those from whom you can sate your hunger, and others... all are balancing acts.
Power structures, politics, everything is a struggle, and interconnected. Vampires will ideally live forever, so how much more connected are they and where do their struggles take them, and what worth do they have?